Which genetic loci are linked to schizophrenia?

Updated: Mar 16, 2018
  • Author: Frances R Frankenburg, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

In a 2014 study, researchers identified new genetic loci not previously known to be associated with schizophrenia. Of the 108 genetic loci linked to schizophrenia that were identified in the study, 83 had not previously been found. The investigators also determined that among 128 independent associations related to the 108 loci, enriched associations existed not only among genes expressed in the brain, but also among those expressed in tissues related to immunity, giving support to the theory linking the immune system to schizophrenia. [17, 18]

Some loci of particular interest include the following:

  • Catechol-O-methyltransferase (COMT) gene

  • RELN gene

  • Nitric oxide synthase 1 adaptor protein (NOS1AP) gene

  • Metabotropic glutamate receptor 3 (GRM3) gene


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