Which medications in the drug class Antidepressants, MAO Inhibitors are used in the treatment of Panic Disorder?

Updated: Mar 21, 2018
  • Author: Mohammed A Memon, MD; Chief Editor: Randon S Welton, MD  more...
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Antidepressants, MAO Inhibitors

Monoamine oxidase inhibitors (MAOIs) are effective in patients with social phobia and refractory anxiety disorders, including panic disorder. Advantages of MAOIs include a low risk of dependence and less anticholinergic effect than tricyclic antidepressants (TCAs). Disadvantages include the higher number of adverse effects, including sexual difficulty, hypotension, weight gain, dry mouth, tachycardia, insomnia, drowsiness, headache, weakness, and constipation.

Phenelzine (Nardil)

Nardil is the MAOI that is most commonly used for managing panic disorder. It has demonstrated clear superiority over placebo in double-blind trials for treating specific symptoms of panic disorder. This drug is usually reserved for patients who do not tolerate or whose condition does not have a response to traditional cyclic or second-generation antidepressants.

Tranylcypromine (Parnate)

Tranylcypromine is also effective against panic disorder. It binds irreversibly to MAO, thereby reducing monoamine breakdown and enhancing synaptic availability.

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