What may improve adherence to buprenorphine maintenance treatment for opioid addiction?

Updated: Jun 21, 2018
  • Author: David W Dixon, DO; Chief Editor: Glen L Xiong, MD  more...
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Answer

Treatment with catechol-O -methyltransferase (COMT) inhibitors may improve adherence to buprenorphine maintenance treatment for opioid addiction. [55] In a study of 253 opiate-dependent patients who had failed to comply with initial buprenorphine maintenance treatment, 186 (73.5%) remained abstinent for longer than 6 months when they received the COMT inhibitor entacapone (200-1000 mg/day) in addition to buprenorphine. Another 61 patients (24.1%) remained abstinent for 12- to 24 months and 41 (16.2%) remained abstinent for 24- to 30 months. Forty-one (16.2%) patients were able to achieve abstinence using long-acting naltrexone. [55] This is the first study of its kind to demonstrate COMT-inhibitors' anticraving effects.


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