What is the role of clonidine in the maintenance treatment of opioid abuse?

Updated: Jun 21, 2018
  • Author: David W Dixon, DO; Chief Editor: Glen L Xiong, MD  more...
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Answer

In August 2015, in a randomized double-blinded placebo-controlled clinical trial, 118 participants maintained on buprenorphine were treated with clonidine or placebo for 14 weeks. Those given clonidine maintained initial abstinence for longer periods than the placebo group, suggesting that clonidine could be a useful adjunctive maintenance treatment alongside buprenorphine by decoupling daily-life stress from increases in drug craving. [42]


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