What is the efficacy of buprenorphine therapy for opioid abuse?

Updated: Jun 21, 2018
  • Author: David W Dixon, DO; Chief Editor: Glen L Xiong, MD  more...
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Answer

One study found that a 4-week buprenorphine taper combined with naltrexone maintenance treatment boosted abstinence rates. [37, 38]

A randomized clinical trial found that patients with prescription opioid dependence whose buprenorphine therapy was tapered were less likely to abstain from illicit opioid use during the 14-week study period than were those who received maintenance therapy. [39] Patients in the taper group reported engaging in a mean of 1.27 days of opioid abuse after the taper, compared with 0.47 days in the maintenance group, and there was a mean of 2.7 consecutive weeks of opioid abstinence in the taper group, compared with 5.2 in the maintenance group.


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