What are the mental status and physiological effects of withdrawal in opioid abuse?

Updated: Jun 21, 2018
  • Author: David W Dixon, DO; Chief Editor: Glen L Xiong, MD  more...
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Mental status effects include purposive behaviors, such as complaints and manipulations directed at getting more drugs, or anxiety.

Physiologic effects include autonomic signs (eg, tachycardia, high blood pressure, fever, piloerection [goose flesh], mydriasis, and lacrimation, CNS arousal (irritability), and yawning.

In milder abstinence syndrome, clinical features may be limited to dysphoria, craving, yawning, lacrimation, rhinorrhea, and restlessness. In moderate-to-severe cases, piloerection, mydriasis, increased BP and pulse, and GI symptoms are seen as well.

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