Which medications in the drug class Orexin Receptor Antagonists are used in the treatment of Sleep-Wake Disorders?

Updated: Aug 21, 2019
  • Author: Roy H Lubit, MD, PhD; Chief Editor: Ana Hategan, MD, FRCPC  more...
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Answer

Orexin Receptor Antagonists

Orexin promotes wakefulness. Antagonism of the orexin receptor suppresses this action by orexin.

Suvorexant

Suvorexant is an orexin receptor antagonist. The orexin neuropeptide signaling system is a central promoter of wakefulness. Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R by suvorexant is thought to suppress wake drive. It is indicated for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.


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