What are the treatment guidelines for omega-3 polyunsaturated fatty acids (PUFAs) as adjunctive therapy for major depressive disorder?

Updated: Oct 07, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

The International Society for Nutritional Psychiatry Research (ISNPR) recommends omega-3 polyunsaturated fatty acids (PUFAs) as adjunctive therapy for major depressive disorder. [219] The recommended therapeutic dosage of pure eicosapentaenoic acid (EPA) is 1–2 g/day (either from pure EPA or a combination of EPA and docosahexaenoic acid [DHA]) for at least 8 weeks as adjunctive treatment. The guideline also endorses n-3 PUFAs as a potential prophylactic treatment for high-risk populations, and indicates that they can be used in overweight patients and those individuals with elevated levels of inflammatory markers.


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