Which medications in the drug class Serotonin-Dopamine Activity Modulators are used in the treatment of Depression?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

Serotonin-Dopamine Activity Modulators

Serotonin-dopamine activity modulators (SDAMs) act as a partial agonist at 5-HT1A and dopamine D2 receptors at similar potency, and as an antagonist at 5-HT2A and noradrenaline alpha1B/2C receptors. This mechanism of action is unique from other atypical antipsychotic drugs.

Brexpiprazole (Rexulti)

Serotonin-dopamine activity modulator (SDAM) indicated as an adjunct treatment for major depressive disorder. Dosage modifications are necessary with renal or hepatic impairment. Dosage modifications are also needed for individuals who are poor metabolizers of CYP2D6, or if coadministered drugs alter metabolism by CYP2D6 or CYP3A4.

Aripiprazole (Abilify, Abilify Discmelt)

Serotonin-dopamine activity modulator (SDAM) indicated as an adjunct treatment for major depressive disorder. Dosage modifications are also needed for individuals who are poor metabolizers of CYP2D6, or if coadministered drugs alter metabolism by CYP2D6 or CYP3A4. No dosage adjustment is required for renal or hepatic impairment.


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