What are the treatment guidelines for depression in patients with personality disorders?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

The following are recommended during the first episode of MDD with comorbid personality disorder:

  • First-intention treatment with SSRI or SNRI (as monotherapy or in combination with psychotherapy)
  • Second-intention treatment with an imipraminic antidepressant or α2 antagonist

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