What are the treatment guidelines for depression in patients with comorbid anxiety disorders?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

Clinical guidelines on the management of depression in patients with psychiatric comorbidities were published in January 2019 by the French Association for Biological Psychiatry and Neuropsychopharmacology and the Fondation FondaMental. [218]

Comorbid anxiety disorders

The following are recommended first-intention strategies during the first episode of major depressive disorder (MDD) with comorbid anxiety disorder:

  • Concurrent treatment of both disorders
  • Use of the same therapist, to the greatest extent possible, for disease management, with treatment including cognitive behavioral therapy, as well as a closer follow-up

First-intention medications and other treatment for MDD with comorbid obsessive-compulsive disorder, panic disorder, social anxiety, generalized anxiety disorder, or posttraumatic stress disorder include the following:

  • Selective serotonin reuptake inhibitor (SSRI)
  • Serotonin and norepinephrine reuptake inhibitor (SNRI)
  • Psychotherapy in combination

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