What are the treatment guidelines for depression in patients with comorbid anxiety disorders?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Clinical guidelines on the management of depression in patients with psychiatric comorbidities were published in January 2019 by the French Association for Biological Psychiatry and Neuropsychopharmacology and the Fondation FondaMental. [218]

Comorbid anxiety disorders

The following are recommended first-intention strategies during the first episode of major depressive disorder (MDD) with comorbid anxiety disorder:

  • Concurrent treatment of both disorders
  • Use of the same therapist, to the greatest extent possible, for disease management, with treatment including cognitive behavioral therapy, as well as a closer follow-up

First-intention medications and other treatment for MDD with comorbid obsessive-compulsive disorder, panic disorder, social anxiety, generalized anxiety disorder, or posttraumatic stress disorder include the following:

  • Selective serotonin reuptake inhibitor (SSRI)
  • Serotonin and norepinephrine reuptake inhibitor (SNRI)
  • Psychotherapy in combination

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