What are the possible adverse effects of tricyclic antidepressants (TCAs)?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

The adverse effects of TCAs, which result largely from their anticholinergic and antihistaminic properties, include the following:

  • Sedation

  • Confusion

  • Dry mouth

  • Orthostasis

  • Constipation

  • Urinary retention

  • Sexual dysfunction

  • Weight gain

Caution should be used in patients with cardiac conduction abnormalities.


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