Is transcranial direct current stimulation (tDCS) an effective treatment for major depressive disorder (clinical depression)?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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In a randomized, double-blind, controlled trial, Brunoni et al found that the efficacy of transcranial direct current stimulation (tDCS) was comparable to that of sertraline (50 mg/day) in the treatment of major depression and that the combination of tDCS with sertraline was superior to sertraline alone. [165] There was a significant difference in depression rating scale score between, on one hand, the combined treatment group and, on the other, the sertraline-only (mean difference, 8.5 points), tDCS only (5.9 points), and placebo groups (11.5 points).

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