What were the AHRQ findings regarding the effectiveness of second-generation antidepressants in the treatment of major depressive disorder (clinical depression)?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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The Agency for Healthcare Research and Quality (AHRQ) compared the effectiveness of the following 12 second-generation antidepressants [117] :

  • Bupropion

  • Citalopram

  • Duloxetine

  • Escitalopram

  • Fluoxetine

  • Fluvoxamine

  • Mirtazapine

  • Paroxetine

  • Sertraline

  • Trazodone

  • Venlafaxine

The AHRQ found that average effectiveness of those 12 antidepressants appeared similar, but the studies reviewed were not designed to test variation among patients’ responses to individual drugs. However, the AHRQ did find moderately strong evidence of differences among individual second-generation antidepressants with respect to onset of action and some measures (eg, sexual functioning) that could affect health-related quality of life.

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