Which tricyclic antidepressants (TCAs) are effective in the treatment of major depressive disorder (clinical depression)?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

TCAs include the following:

  • Amitriptyline (Elavil)

  • Clomipramine (Anafranil)

  • Desipramine (Norpramin)

  • Doxepin (Sinequan)

  • Imipramine (Tofranil)

  • Nortriptyline (Pamelor)

  • Protriptyline (Vivactil)

  • Trimipramine (Surmontil)

TCAs have a long record of efficacy in the treatment of depression. They are used less commonly because of their side-effect profile and their considerable toxicity in overdose (see AntidepressantToxicity).


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