What is the role of substance use in major depressive disorder (clinical depression)?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Substance use, abuse, or dependence can cause significant mood symptoms. This is especially true of alcohol, cocaine, amphetamines, cannabinoids, sedatives/hypnotics, and narcotics. Inhalant abuse should also be considered, particularly among young male patients. Other substance-related and psychiatric processes either can present with mood disturbance as the primary symptom or can occur together with major depressive disorder.

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