Which medications produce changes in mood?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Pharmacologic agents can produce changes in mood. These substances include the following:

  • Antihypertensive medications (especially reserpine and methyldopa)

  • Smoking-cessation aids (eg, varenicline)

  • Steroids

  • Sex hormones and medications that affect sex hormones (eg, estrogen, progesterone, testosterone, gonadotropin-releasing hormone [GnRH] antagonists)

  • H2 blockers (eg, ranitidine, cimetidine)

  • Sedatives

  • Muscle relaxants

  • Appetite suppressants

  • Chemotherapy agents (eg, vincristine, procarbazine, L-asparaginase, interferon, vinblastine)

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