How is depression with melancholic features defined in the DSM-5?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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In depression with melancholic features, either a loss of pleasure in almost all activities or a lack of reactivity to usually pleasurable stimuli is present. Additionally, at least 3 of the following are required:

  • A depressed mood that is distinctly different from the kind that is felt when a loved one is deceased

  • Depression that is worse in the morning

  • Waking up 2 hours earlier than usual

  • Observable psychomotor retardation or agitation

  • Significant weight loss or anorexia

  • Excessive or inappropriate guilt

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