What are the DSM-5 criteria for diagnosis of major depressive disorder (clinical depression)?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

The specific DSM-5 criteria for major depressive disorder are outlined below.

At least 5 of the following symptoms have to have been present during the same 2-week period (and at least 1 of the symptoms must be diminished interest/pleasure or depressed mood) [2] :

  • Depressed mood: For children and adolescents, this can also be an irritable mood

  • Diminished interest or loss of pleasure in almost all activities (anhedonia)

  • Significant weight change or appetite disturbance: For children, this can be failure to achieve expected weight gain

  • Sleep disturbance (insomnia or hypersomnia)

  • Psychomotor agitation or retardation

  • Fatigue or loss of energy

  • Feelings of worthlessness

  • Diminished ability to think or concentrate; indecisiveness

  • Recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt or specific plan for committing suicide

The symptoms cause significant distress or impairment in social, occupational or other important areas of functioning.

The symptoms are not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication) or another medical condition.

The disturbance is not better explained by a persistent schizoaffective disorder, schizophrenia, delusional disorder, or other specified or unspecified schizophrenia spectrum and other psychotic disorders

There has never been a manic episode or a hypomanic episode


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