What is the effect of comorbidities on the prognosis of older patients with major depressive disorder (clinical depression)?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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In older patients, depression is frequently comorbid with chronic medical conditions and can lead to worsening medical outcomes, including mortality. [28] For example, coronary artery disease is a risk factor for the development of depression, and depression is an independent risk factor for the development of coronary disease. Patients with both conditions are more likely to die than those with coronary artery disease alone. Both behavioral and physiologic explanations are likely for these associations. [60]

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