What is the vascular depression hypothesis?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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The vascular depression hypothesis posits that cerebrovascular disease may cause or contribute to late-life depression. Various lines of evidence support this hypothesis, including the following [46] :

  • Higher incidence of depression following a left-sided stroke

  • Higher prevalence of ischemic white-matter changes in older adults with depression than those without

  • Bidirectional association between depression and coronary artery disease and depression and diabetes

  • Higher rates of depression among patients with vascular dementia than those with Alzheimer disease

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