What is the role of the neurotransmitter system in the development of major depressive disorder (clinical depression)?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

Possible abnormalities of the neurotransmitter systems remain under investigation. Compared with control subjects, depressed prepubertal children had lower cortisol secretion during the first 4 hours of sleep, according to De Bellis et al. Nocturnal secretion of adrenocorticotropin, growth hormone, and prolactin did not differ between the 2 groups. [41]


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