Why do patients treated with an SSRI for major depressive disorder (clinical depression) discontinue treatment or switch medications?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Approximately 40% of patients who are treated with a selective serotonin reuptake inhibitor (SSRI) will either discontinue treatment or switch medications because of an adverse effect of the medication. In one study, an increased risk for sexual dysfunction from SSRIs was found to be associated with alleles in the 5HT2A and GHB3 genes. [30]

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