What is the role of the gene FKBP5 in the etiology of major depressive disorder (clinical depression)?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

A study of genes in the hypothalamic-pituitary-adrenal axis found that in patients with major depression, homozygosity for the T allele in the FKBP5 gene was associated with a quicker response to antidepressants than heterozygosity or homozygosity for the C allele in that location. However, homozygosity for the T allele was also associated with an increased recurrence of depressive episodes. [23]


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