Which susceptibility loci have been identified for major depressive disorder (clinical depression)?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

Two susceptibility loci have been identified in which no specific gene of interest has been definitively identified. The MDD1 locus is located at 12q22-q23.2 and is most strongly linked to major depression in males. [16] The MDD2 locus is located at 15q25.2-q26.2 and has been associated with early onset or recurrent episodes of depression. [17]


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