Which abnormalities were found in brain regions during a major depressive episode?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Both functional and structural abnormalities were found in the same brain region during a major depressive episode. Sacher et al found increases in glucose metabolism in the right subgenual and pregenual anterior cingulate cortices and decreased gray matter volumes in the amygdala, dorsal frontomedian cortex, and right paracingulate cortex. [13]

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