In which areas of the brain is activity diminished in unipolar depression and bipolar depression?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

In one study, positron emission tomographic (PET) images showed abnormally diminished activity in an area of the prefrontal cortex in patients with unipolar depression and bipolar depression. This region is related to emotional response and has widespread connections with other areas of the brain, including the areas that appear to be responsible for the regulation of DA, noradrenaline (locus ceruleus), and 5-HT (raphe nuclei). [13]


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