What changes in brain structures have been reported in major depressive disorder (clinical depression)?

Updated: Mar 28, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

A meta-analysis comparing brain structures in patients with major depression, in healthy controls, and in patients with bipolar disorder demonstrated associations between depression and increased lateral ventricle size, larger cerebrospinal fluid volume, and smaller volumes of the basal ganglia, thalamus, hippocampus, frontal lobe, orbitofrontal cortex, and gyrus rectus. Patients experiencing a depressive episode had smaller hippocampal volume than those in remission. [12]


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