What is the role of vascular lesions in the pathogenesis of major depressive disorder (clinical depression)?

Updated: Oct 07, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

Vascular lesions may contribute to depression by disrupting the neural networks involved in emotion regulation—in particular, frontostriatal pathways that link the dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate, and dorsal cingulate. [10] Other components of limbic circuitry, in particular the hippocampus and amygdala, have been implicated in depression.


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