What drugs are used for the treatment of major depressive disorder (clinical depression)?

Updated: Aug 06, 2020
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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In all patient populations, the combination of medication and psychotherapy generally provides the quickest and most sustained response. [3, 4]


Drugs used for treatment of depression include the following:

  • Selective serotonin reuptake inhibitors (SSRIs)

  • Serotonin/norepinephrine reuptake inhibitors (SNRIs)

  • Atypical antidepressants

  • Tricyclic antidepressants (TCAs)

  • Monoamine oxidase inhibitors (MAOIs)

  • N-methyl-D-aspartate (NMDA) receptor antagonists

  • St. John's wort (Hypericum perforatum)

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