Which medications in the drug class Antipsychotics, Phenothiazine are used in the treatment of Bipolar Disorder?

Updated: May 30, 2019
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Antipsychotics, Phenothiazine

Phenothiazine antipsychotics, which are classified as first-generation antipsychotics, are efficacious for treating both psychotic and nonpsychotic manic and mixed episodes, as well as hypomania.


Chlorpromazine is used to treat manic and mixed episodes in patients with bipolar I disorder. It can be used alone or in combination with lithium or valproate. Chlorpromazine blocks postsynaptic dopamine receptors (D2) in the mesolimbic system and increases dopamine turnover by blockade of the D2 somatodendritic autoreceptor

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