What are the most efficacious treatments for bipolar affective disorder (manic-depressive illness)?

Updated: May 30, 2019
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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According to a multiple treatments meta-analysis of treatments for acute mania, the most efficacious treatments are haloperidol, risperidone, and olanzapine, significantly outperforming primary mood stabilizers and other antipsychotic medications. [100] In several randomized, double-blind, controlled studies, olanzapine monotherapy was significantly more effective in treating manic or mixed episodes than haloperidol [101] or divalproex monotherapy. [102] The adjunctive use of olanzapine with divalproex or lithium, [103] or of risperidone with divalproex or lithium, was also significantly more effective than divalproex or lithium alone. [104, 105]

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