What is the role of creatinine and blood urea nitrogen (BUN) levels in the diagnosis of bipolar affective disorder (manic-depressive illness)?

Updated: May 06, 2018
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

Kidney failure can present as depression. Treatment with lithium can affect urinary clearances, and serum creatinine and blood urea nitrogen (BUN) levels can increase; however, other signs and symptoms of kidney failure will appear first. Carefully and regularly monitor renal function.


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