What is the role of thyroid tests in the diagnosis of bipolar affective disorder (manic-depressive illness)?

Updated: May 06, 2018
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

Thyroid tests are performed to rule out hyperthyroidism (mania) and hypothyroidism (depression). Treatment with lithium can cause hypothyroidism, and hypothyroidism may cause rapid cycling of mood, especially in women.

In a study to assess the relationship between bipolar disorder and thyroid dysfunction, Krishna et al found that elevated T3 hormone had a statistically significantly association with bipolar disorder. [73] In fact, patients with bipolar disorder were 2.55 times more commonly associated with thyroid dysfunction than individuals without bipolar disorder. [73]


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