What is the role of thyroid tests in the diagnosis of bipolar affective disorder (manic-depressive illness)?

Updated: May 30, 2019
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Thyroid tests are performed to rule out hyperthyroidism (mania) and hypothyroidism (depression). Treatment with lithium can cause hypothyroidism, and hypothyroidism may cause rapid cycling of mood, especially in women.

In a study to assess the relationship between bipolar disorder and thyroid dysfunction, Krishna et al found that elevated T3 hormone had a statistically significantly association with bipolar disorder. [73] In fact, patients with bipolar disorder were 2.55 times more commonly associated with thyroid dysfunction than individuals without bipolar disorder. [73]

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