Which factors are associated with a worse prognosis for bipolar affective disorder (manic-depressive illness)?

Updated: May 30, 2019
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Factors suggesting a worse prognosis include the following:

  • Poor job history

  • Substance abuse

  • Psychotic features

  • Depressive features between periods of mania and depression

  • Evidence of depression

  • Male sex

  • Pattern of depression-mania-euthymia

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