What is the etiologic relationship between substance-induced psychosis and bipolar affective disorder (manic-depressive illness [manic-depressive illness])?

Updated: May 30, 2019
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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One study found that as many as a third of all patients with substance use-induced psychosis may go on to develop schizophrenia or bipolar disorder within five years. Researchers studied 6,788 patients who received a diagnosis of substance-induced psychosis over a 20-year period and who did not have any previous record of treatment for schizophrenia spectrum disorders or bipolar disorder. Overall, 32.2% of all patients with substance use-induced psychosis converted to either schizophrenia or bipolar disorder. Cannabis-induced psychosis carried the highest risk of conversion for patients at a rate of 47.4%. [50]

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