What is the genetic component to the etiology of bipolar affective disorder (manic-depressive illness)?

Updated: May 06, 2018
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

Bipolar disorder, especially bipolar type I (BPI) disorder, has a major genetic component, with the involvement of the ANK3,CACNA1C, and CLOCK genes. [18, 19, 20, 16, 17, 25, 43] The evidence indicating a genetic role in bipolar disorder takes several forms.


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