How does deletions throughout the genome increase the risk for bipolar affective disorder (manic-depressive illness)?

Updated: May 06, 2018
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

When investigators looked at microarray results for 1001 patients with bipolar disorder and 1033 controls to quantify the risk of deletions throughout the genome for patients with bipolar disorder, they found that 16.2% of patients with bipolar disorder had deletions, whereas 12.3% of controls had deletions. In addition, patients who had bipolar disorder and deletions more frequently had onset of mania before age 18 years. [4]


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