What is the association between large copy number genetic variants and bipolar affective disorder (manic-depressive illness)?

Updated: May 30, 2019
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

Of additional interest, a number of studies suggest that certain large copy number variants (greater than 100 kb) (includes both deletions and duplications) are associated with psychiatric disease, with bipolar disease and schizophrenia being the most commonly associated. [32] The implication is that possession of one of these copy number variants may modify the phenotype to those who are at risk of psychiatric disease. [32]


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