What is the role of estrogen receptor binding site variation in the pathophysiology of bipolar affective disorder (manic-depressive illness) in females?

Updated: May 06, 2018
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

Although most of the present research does not stratify by sex, a recent study looked at association between estrogen receptor binding site variation with bipolar disorder in females. In particular, the association is with the transglutaminase 2 (TGM2) gene, which is known to be under estrogenic control. [31] This is further evidence of the heterogeneity of bipolar disorder and also presents evidence to explain the differences in the epidemiology of bipolar disorder between women and men.


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