What is the role of the NCAN gene in the pathophysiology of bipolar affective disorder (manic-depressive illness)?

Updated: May 30, 2019
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Newer GWASs continue to find additional genes of interest which appear to be associated with an increased risk of bipolar disorder. One study showed an association between bipolar disorder and the NCAN gene. [30] This gene is expressed in the brain and is involved in the migration of cells within the brain. In a mouse model, it was observed that the NCAN product is most prevalent in the hippocampus. There was no phenotypic defect in NCAN -deficient mice, but subtle effects could not be excluded. [30]

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