What is the evidence of single-nucleotide polymorphisms (SNPs) as etiologic factors in bipolar affective disorder (manic-depressive illness)?

Updated: May 30, 2019
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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In 2013, the Cross-Disorder Group of the Psychiatric Genomics Consortium published results of their large GWAS study of psychiatric disorders, reporting that specific single-nucleotide polymorphisms (SNPs) are associated with range of childhood- or adult-onset psychiatric disorders. [23] The study comprised a combined sample of 33,332 persons with schizophrenia, bipolar disorder, major depression, attention deficit disorder and autism spectrum disorders and 27,888 controls of European ancestry. [23]

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