What is the evidence of common susceptibility genes for bipolar affective disorder (manic-depressive illness) and schizophrenia?

Updated: May 06, 2018
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

A joint analysis of the bipolar GWAS data was carried out, including GWAS data from another large-scale study of schizophrenia published in the same issue. Again, both ANK3 and CACNA1C came up positive in the combined data set, suggesting a shared genetic basis for these disorders. A previous National Institutes of Health (NIH) report on GWASs also underscored that bipolar disorder and schizophrenia could indeed share common susceptibility genes on chromosome 6. [22]


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