What is the role of paroxetine (Paxil) in the treatment of anxiety disorders?

Updated: Mar 27, 2019
  • Author: Nita V Bhatt, MD, MPH; Chief Editor: David Bienenfeld, MD  more...
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Answer

Paroxetine (Paxil) represents a partially sedating SSRI option that is also available in a controlled-release preparation (Paxil CR), which may improve tolerability, but paroxetine still inhibits P450 2D6. Paroxetine has a short half-life, which may be a limitation in marginally compliant patients.


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