Which medications in the drug class Aldehyde dehydrogenase inhibitors are used in the treatment of Alcoholism?

Updated: Mar 23, 2020
  • Author: Warren Thompson, MD, FACP; Chief Editor: Glen L Xiong, MD  more...
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Aldehyde dehydrogenase inhibitors

Disulfiram inhibits aldehyde dehydrogenase, and, as a result, acetaldehyde accumulates. This leads to nausea, hypotension, and flushing if a person drinks alcohol while taking disulfiram.

Disulfiram (Antabuse)

Decreases number of drinking days but does not increase abstinence. Directly observed therapy might be more beneficial but has not been studied in a good randomized trial.

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