What is the antimicrobial regimen used for prophylaxis in the perioperative management of cardiac patients?

Updated: Feb 04, 2019
  • Author: Davinder Jassal, MD; Chief Editor: William A Schwer, MD  more...
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Answer

Answer

The following antimicrobial regimen is suggested for prophylaxis:

  • Dental, oral, or upper respiratory tract procedures -Amoxicillin 2 g PO 1 hour prior to the procedure; if allergic to penicillin, alternatives include clindamycin 600 mg PO, cephalexin 2 g PO, or azithromycin 500 mg PO 1 hour prior to the procedure

  • Genitourinary or gastrointestinal procedures -Ampicillin 2 g IV and gentamicin 1.5 mg/kg 30 min prior to procedure, followed by amoxicillin 1 g PO/IV/IM 8 hours later; if allergic to penicillin, alternatives include vancomycin 1 g IV and gentamicin 1.5 mg/kg 1-2 hours prior to the procedure


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