What is the efficacy of a periprocedural bridging strategy with low-molecular-weight heparin (LMWH) for the management of anticoagulation?

Updated: May 08, 2018
  • Author: Brian J Daley, MD, MBA, FACS, FCCP, CNSC; Chief Editor: William A Schwer, MD  more...
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Answer

Answer

A 2014 randomized study by Di Biase was the first study showing that performing catheter ablation of atrial fibrillation (AF) without warfarin discontinuation reduces the occurrence of periprocedural stroke and minor bleeding complications compared with bridging with low-molecular-weight heparin (LMWH). [2]

A National Heart, Lung, and Blood Institute (NHLBI)–sponsored study showed that a periprocedural bridging strategy with low-molecular-weight heparin (LMWH) offered no clinical advantages compared with interrupting warfarin treatment. [3, 4]


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