Which therapeutic approaches are under investigation for the treatment of glioblastoma multiforme (GBM)?

Updated: Jul 28, 2021
  • Author: Jeffrey N Bruce, MD; Chief Editor: Herbert H Engelhard, III, MD, PhD, FACS, FAANS  more...
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The limited efficacy of current therapeutic options for glioblastoma multiforme (GBM) has prompted research into alternative approaches. Therapy modalities under investigation include the following [8] :

  • Targeted molecular therapies
  • Immunotherapy (eg, vaccines, checkpoint inhibitors, oncolytic viruses) [111]
  • Nanomedicines that can cross the blood-brain barrier [112]
  • Stem cells [113]
  • Cannabinoids [114]
  • Ketogenic diet [115]

Genotyping of brain tumors may have applications in stratifying patients for clinical trials of various novel therapies. In about 50% of patients with glionas, circulating tumor DNA can be sequenced from cerebrospinal fluid, allowing genotyping of the tumor without the need for brain re-biopsy. [116]

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