What are the preferred chemotherapy agents for the treatment of glioblastoma multiforme (GBM)?

Updated: Jul 28, 2021
  • Author: Jeffrey N Bruce, MD; Chief Editor: Herbert H Engelhard, III, MD, PhD, FACS, FAANS  more...
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Answer

Chemotherapy for recurrent glioblastoma multiforme provides modest benefit at best. Agents from several classes are used. According to the National Comprehensive Cancer Network, preferred agents include the following [58] :

  • Bevacizumab
  • Temozolomide
  • Lomustine or carmustine
  • PCV (procarbazine, lomustine [CCNU], vincristine)
  • Regorafenib

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