Which genetic abnormalities result in more malignant glioblastomas?

Updated: Jul 01, 2019
  • Author: Jeffrey N Bruce, MD; Chief Editor: Herbert H Engelhard, III, MD, PhD, FACS, FAANS  more...
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Answer

Less frequent but more malignant mutations in glioblastomas include the following:

  • MMAC1-E1 - A gene involved in the progression of gliomas to their most malignant form

  • MAGE-E1 - A glioma-specific member of the MAGE family that is expressed at up to 15-fold higher levels in glioblastoma multiformes than in normal astrocytes

  • NRP/B - A nuclear-restricted protein/brain, which is expressed in neurons but not in astrocytes (NRP/B mutants are found in glioblastoma cells.)


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